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MODELING ALGORITHM OF ESTIMATION OF RENAL FUNCTION BY THE COCKCROFT AND MDRD FORMULAS

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    Title: MODELING ALGORITHM OF ESTIMATION OF RENAL FUNCTION BY THE COCKCROFT AND MDRD FORMULAS
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    Date: 5 / 2013
    Publication type: Journal article
    Authors:
    No. First name Last name Show
    1. Boumediene Selma
    2. Samira Chouraqui
    3. Ahmed Ghali
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    Keywords
    1. Cockcroft-Gault formula
    2. GFR
    3. MDRD formula
    4. creatinine
    5. renal function

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    Abstract

    The purpose of this study was to determine the concordance between two equations used for estimating glomerular filtration rate, in order to verify the possibility to be used interchangeably in the clinical practice. The two equations are of Cockcroft & Gault (CG) (1976) formula and MDRD (modification of Diet in Renal Disease) (1999) formula, these two models allow the assessment of glomerular filtration rate (GFR) by calculating creatinine clearance (CLCR).To make a comparison between these two formulas different models were examined for Subjects with normal renal function, Patients with renal impairment, Diabetic patients, Age and sex, finally lean and obese patients by modeling two algorithms with the two functions. Results show that the formula of Cockcroft & Gault remains the method of choice for estimating renal function in clinical practice.