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The purpose of this study was to determine the concordance between two equations used for estimating
glomerular filtration rate, in order to verify the possibility to be used interchangeably in the clinical
practice. The two equations are of Cockcroft & Gault (CG) (1976) formula and MDRD (modification of
Diet in Renal Disease) (1999) formula, these two models allow the assessment of glomerular filtration rate
(GFR) by calculating creatinine clearance (CLCR).To make a comparison between these two formulas
different models were examined for Subjects with normal renal function, Patients with renal impairment,
Diabetic patients, Age and sex, finally lean and obese patients by modeling two algorithms with the two
functions. Results show that the formula of Cockcroft & Gault remains the method of choice for estimating
renal function in clinical practice.